Discussion
Nowadays the use of biomarkers, especially PCA3, in identification csPCa is actively discussed [1, 2, 6, 14, 19, 20]. L.S. Marks et al. (2008) described the principles of the urine collection for PCA3 test [16]. We suppose that this may be the main limitation in cases with anterior TGDP PCa. So, in this study design we decided to be in consensus with our colleagues’ recommendations in terms of distinguishing TZO and TGDP in PCa patients [7, 8, 22, 23, 26]. The results of our previous work demonstrated differences in PCA3 urine levels between aPZ-PCa and pPZ-PCa, as well as, pPZ-PCa correlations with pISUP [21]. In this work we founnd PCA3 optimal values for identifiying pPZ-csPCa according to the pISUP class. Which can be usefull for choosing the optimal treatment way in patients with localized PCa. PCA3 is well known biomarker, which routinely used for PCa diagnosis [5, 1].
Conclusion
PCA3 urine levels can be used to identify pPZ-csPCa patients according to the postoperative ISUP-class. Further investigations may show a knew PCA3 test performance.
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